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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
22.73
Human Site:
Y495
Identified Species:
45.45
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
Y495
D
Q
K
W
T
R
H
Y
C
A
I
A
D
A
K
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
Y495
D
Q
K
W
T
R
H
Y
C
A
I
A
D
A
K
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
Y495
D
Q
K
W
T
R
H
Y
C
A
I
A
D
A
K
Dog
Lupus familis
XP_546812
1252
146274
Y495
D
Q
K
W
T
R
H
Y
C
A
I
A
D
A
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
Y495
D
Q
K
W
T
R
H
Y
C
A
I
A
D
A
K
Rat
Rattus norvegicus
P24135
1265
147716
Y495
D
Q
K
W
T
R
H
Y
C
A
I
A
D
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
R254
K
F
I
D
D
T
M
R
E
T
A
E
P
F
L
Chicken
Gallus gallus
Q2VRL0
637
72514
Frog
Xenopus laevis
Q32NH8
758
87399
G21
N
L
Q
L
M
Q
A
G
S
P
M
R
K
V
K
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
M47
M
L
Q
G
S
K
M
M
K
V
R
S
Q
R
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
I397
V
D
E
T
S
F
L
I
R
N
D
E
S
R
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
N203
P
W
F
H
G
K
L
N
T
N
A
D
Q
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
0
6.6
0
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
0
33.3
26.6
N.A.
N.A.
20
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
50
17
50
0
50
0
% A
% Cys:
0
0
0
0
0
0
0
0
50
0
0
0
0
0
0
% C
% Asp:
50
9
0
9
9
0
0
0
0
0
9
9
50
0
0
% D
% Glu:
0
0
9
0
0
0
0
0
9
0
0
17
0
0
0
% E
% Phe:
0
9
9
0
0
9
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
9
9
0
0
9
0
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
0
50
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
9
0
0
50
0
0
0
0
% I
% Lys:
9
0
50
0
0
17
0
0
9
0
0
0
9
0
59
% K
% Leu:
0
17
0
9
0
0
17
0
0
0
0
0
0
9
9
% L
% Met:
9
0
0
0
9
0
17
9
0
0
9
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
9
0
17
0
0
0
0
0
% N
% Pro:
9
0
0
0
0
0
0
0
0
9
0
0
9
0
9
% P
% Gln:
0
50
17
0
0
9
0
0
0
0
0
0
17
0
9
% Q
% Arg:
0
0
0
0
0
50
0
9
9
0
9
9
0
17
0
% R
% Ser:
0
0
0
0
17
0
0
0
9
0
0
9
9
0
0
% S
% Thr:
0
0
0
9
50
9
0
0
9
9
0
0
0
0
0
% T
% Val:
9
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% V
% Trp:
0
9
0
50
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _